Select Publications

IL (Interleukin)-17A Acts in the Brain to Drive Neuroinflammation, Sympathetic Activation, and Hypertension.
Cao Y, Yu Y, Xue B, Wang Y, Chen X, Beltz TG, Johnson AK, Wei SG. Hypertension. 2021 Nov;78(5):1450-1462. doi: 10.1161/HYPERTENSIONAHA.121.18219. Epub 2021 Oct 11.PMID: 34628936

Maternal Angiotensin II-Induced Hypertension Sensitizes Postweaning High-Fat Diet-Elicited Hypertensive Response Through Increased Brain Reactivity in Rat Offspring.
Xue B, Yu Y, Beltz TG, Guo F, Felder RB, Wei SG, Kim Johnson A.  J Am Heart Assoc. 2021 Sep 21;10(18):e022170. doi: 10.1161/JAHA.121.022170. Epub 2021 Sep 6.PMID: 34482712

Silencing Epidermal Growth Factor Receptor in Hypothalamic Paraventricular Nucleus Reduces Extracellular Signal-regulated Kinase 1 and 2 Signaling and Sympathetic Excitation in Heart Failure Rats.
Yu Y, Wei SG, Weiss RM, Felder RB.  Neuroscience. 2021 May 21;463:227-237. doi: 10.1016/j.neuroscience.2021.01.025. Epub 2021 Feb 2.PMID: 33540053

TNF-α-induced sympathetic excitation requires EGFR and ERK1/2 signaling in cardiovascular regulatory regions of the forebrain.
Wei SG, Yu Y, Felder RB.  Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H772-H786. doi: 10.1152/ajpheart.00606.2020. Epub 2020 Dec 18.PMID: 33337962

Predator Scent-Induced Sensitization of Hypertension and Anxiety-like Behaviors.
Xue B, Xue J, Yu Y, Wei SG, Beltz TG, Felder RB, Johnson AK.  Cell Mol Neurobiol. 2020 Nov 17:10.1007/s10571-020-01005-y. doi: 10.1007/s10571-020-01005-y. Online ahead of print.PMID: 33201417

An Injectable Microparticle Formulation Provides Long-Term Inhibition of Hypothalamic ERK1/2 Activity and Sympathetic Excitation in Rats with Heart Failure.
Naguib YW, Yu Y, Wei SG, Morris A, Givens BE, Mekkawy AI, Weiss RM, Felder RB, Salem AK.  Mol Pharm. 2020 Sep 8;17(9):3643-3648. doi: 10.1021/acs.molpharmaceut.0c00501. Epub 2020 Aug 4.PMID: 32786958

Stress-Induced Sensitization of Angiotensin II Hypertension Is Reversed by Blockade of Angiotensin-Converting Enzyme or Tumor Necrosis Factor-α.
Xue B, Yu Y, Wei SG, Beltz TG, Guo F, Felder RB, Johnson AK.  Am J Hypertens. 2019 Aug 14;32(9):909-917. doi: 10.1093/ajh/hpz075.PMID: 31063551

Brain TACE (Tumor Necrosis Factor-α–Converting Enzyme) Contributes to Sympathetic Excitation in Heart Failure Rats.
Yu Y, Cao Y, Bell B, Chen X, Weiss RM, Felder RB, Wei SG. Hypertension. 2019 Jul;74(1):63-72. doi: 10.1161/HYPERTENSIONAHA.119.12651. Epub 2019 Jun 3. PMID: 31154904.

Stress-induced sensitization of angiotensin II hypertension is reversed by blockade of angiotensin-converting enzyme or tumor necrosis factor-α.
Xue B, Yu Y, Wei SG, Beltz TG, Guo F, Felder RB, Johnson AK. Am J Hypertens. 2019 Aug 14;32(9):909-917. doi: 10.1093/ajh/hpz075.  PMID: 31063551.

Sex differences in the central and peripheral manifestations of ischemia-induced heart failure in rats.
Yu Y, Wei SG, Weiss RM, Felder RB. Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H70-H79. doi: 10.1152/ajpheart.00499.2018. Epub 2018 Oct 5. PMID: 30289294

Angiotensin II Type 1a Receptors in the Subfornical Organ Modulate Neuroinflammation in the Hypothalamic Paraventricular Nucleus in Heart Failure Rats.
Yu Y, Wei SG, Weiss RM, Felder RB. Neuroscience. 2018 Jun 15;381:46-58. doi: 10.1016/j.neuroscience.2018.04.012. Epub 2018 Apr 21. PMID: 29684507

Blood-borne interleukin-1β acts on the subfornical organ to upregulate the sympathoexcitatory milieu of the hypothalamic paraventricular nucleus.
Wei SG, Yu Y, Felder RB.  Am J Physiol Regul Integr Comp Physiol. 2018 Mar 1;314(3):R447-R458. doi: 10.1152/ajpregu.00211.2017. Epub 2017 Nov 22. PMID: 29167166

TNF-α receptor 1 knockdown in the subfornical organ ameliorates sympathetic excitation and cardiac hemodynamics in heart failure rats.
Yu Y, Wei SG, Weiss RM, Felder RB. Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H744-H756. doi: 10.1152/ajpheart.00280.2017. Epub 2017 Jul 14. PMID: 28710070

Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin-angiotensin system activity and sympathetic nerve activity in heart failure.
Wei SG, Yu Y, Weiss RM, Felder RB. Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H871-H880. doi: 10.1152/ajpheart.00362.2016. Epub 2016 Aug 5.  PMID: 27496879

ERK1/2 MAPK signaling in hypothalamic paraventricular nucleus contributes to sympathetic excitation in rats with heart failure after myocardial infarction. 
Yu Y, Wei SG, Zhang ZH, Weiss RM, Felder RB. Am J Physiol Heart Circ Physiol. 2016 Mar 15;310(6):H732-9. doi: 10.1152/ajpheart.00703.2015. Epub 2016 Jan 22. PMID: 26801309

Inhibition of Brain Mitogen-Activated Protein Kinase Signaling Reduces Central Endoplasmic Reticulum Stress and Inflammation and Sympathetic Nerve Activity in Heart Failure Rats.
Wei SG, Yu Y, Weiss RM, Felder RB.  Hypertension. 2016 Jan;67(1):229-36. doi: 10.1161/HYPERTENSIONAHA.115.06329. Epub 2015 Nov 16. PMID: 26573710

Proinflammatory cytokines upregulate sympathoexcitatory mechanisms in the subfornical organ of the rat.
Wei SG, Yu Y, Zhang ZH, Felder RB. Hypertension. 2015 May;65(5):1126-33. doi: 10.1161/HYPERTENSIONAHA.114.05112. Epub 2015 Mar 16. PMID: 25776070